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Eli Lilly and Company. CYRAMZA® product monograph. Indianapolis, Indiana, USA Ramucirumab (LY3009806, IMC-1121B, trade name Cyramza) is a fully human monoclonal antibody (IgG1) developed for the treatment of solid tumors. This drug was developed by ImClone Systems Inc. It was isolated from a native phage display library from Dyax .
negative/unknown), and geographical region (the Americas vs. Europe/Australia/New Zealand vs. Asia/Middle East/Africa).When 25%, 50%, and 75% of the expected events are observed, 3 interim Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). Buy VEGFR/PDGFR inhibitor Ramucirumab (LY3009806; IMC-1121B) from AbMole BioScience. PURPOSE To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics, and preliminary anticancer activity of ramucirumab (IMC-1121B), a fully human immunoglobulin G(1) monoclonal antibody targeting the vascular endothelial growth factor receptor (VEGFR)-2. 1.
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2014 Aug;50(12):2099-107. doi: 10.1016/j.ejca.2014.03.289. Epub 2014 Jun 12.
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